Immune system stimulator
Emerging evidences suggest that artemisinin and its derivatives possess (artemisinin and its derivatives) an immunomodulatory effect during either innate and adaptive immune responses in diverse cell types. Relevant scientific publications have shown that artemisinin compounds have the ability to modulate the immune response by regulating cell proliferation and reducing the production of proinflammatory cytokines and chemokines that directly will benefit the host. Moreover, other scientific studies have revealed how artemisinin stimulates TH1 immune pathway by activating the generation of T helper lymphocytes (CD4 and CD8), NK and IFN-gamma in both the spleen and circulation. Finally, some other findings indicate that artemisinin and some derivatives could be used as new candidate adjuvants, therefore contributing to the immune response for patients on either pharmacological curative or preventive treatments.
Consequently, artemisinin and its derivatives arise as a promising alternative to enhance cellular immune responses under non-pathological or pathological conditions due to their anti-inflammatory and immunoregulatory properties.