Lyme Disease

Lyme disease is caused by the Borrelia burgdorferi bacteria, and is presently the most common disease transmitted by ticks to humans in the Northern Hemisphere. Currently, antibiotics are becoming less effective and the vaccine is no longer effective at all. Clinical trials using artemisinin in combination with cefoperazone and doxycycline have just started (phase I).

References:

• Puri et al., 2017;
• Feng et al. 2016;
• Feng et al. 2015;
• Stanek et al., 2012.

Coccidiosis

This is a disease of the intestinal tract of animals caused by Coccidian protozoa. It affects domestic fowl and thus has huge economic implications for the European Union. A combination of different, secondary metabolites from mature Artemisia annua leaves (artemisinin, camphor, 1,8-cineole and artemisia ketone) are showing promising results for the treatment of several infectious diseases in animals, such as coccidiosis, necrotic enteritis, cándida or acanthamoebiasis).

References:

• Fatemi et al., 2017;
• Pop et al., 2015;
• Kaboutari et al., 2014;
• Kappagoda et al., 2011;
• Shahbazfar et al., 2011.